Latest Research Results
List of Papers
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2026.07/17
Thermo-Sensing Mechanisms of Splicing Control by Nuclear Stress Bodies
Ueno T, Adachi S, Taniguchi I, Noda NN, Ninomiya K, and Hirose T.
Molecular Cell (2026)
DOI: 10.1016/j.molcel.2026.06.034 -
2026.07/02
Abnormally long mitochondria leak RNA: activating anti-tumor immunity
T. Yasuda, A. Ichikawa, K. Onoue, E. Ogasawara, T. Ishihara, H. Kosako, N. Ishihara.
Cell Rep. (2026)
DOI: 10.1016/j.celrep.2026.117607 -
2026.04/28
Two proteins, one goal: new findings on stem cell differentiation
Ito, T., Yoshino, M., Isobe, S.-Y., & Obuse, C.
Cell Reports (2026)
DOI: https://doi.org/10.1016/j.celrep.2026.117293 -
2026.01/13
Changes in genetic structure of yeast lead to disease-causing genomic instabilities
Ran Xu, Crystal Tang, Jianfang N. Wang, Daisuke Motooka, Hideo Tsubouchi, Hiroshi Iwasaki, and Takuro Nakagawa
Nucleic Acids Research (2026)
DOI: https://doi.org/10.1093/nar/gkaf1455 -
2025.08/29
Variation inside and out: cell types in fruit fly metamorphosis
Daiki Wakita, Satoshi Yamaji, Daiki Umetsu and Takeshi Kano
PLOS Computational Biology (2025)
DOI: https://doi.org/10.1371/journal.pcbi.1013331 -
2025.08/04
Discovery of the “switch” that activate plant stem cells
Shimadzu S, Yonekura T, Furuya T, Kojima M, Ishizaki K, Asahina M, Ohashi-Ito K, Sakakibara H, Fukaki H, Fukuda H, Kondo Y.
Nature Plants (2025)
DOI: https://doi.org/10.1038/s41477-025-02051-4 -
2025.07/15
Winter survival: Brain peptide called corazonin stops bug reproduction
Xi Jili, Hamanaka Yoshitaka, and Shiga Sakiko.
Journal of Experimental Biology (2025)
DOI: https://doi.org/10.1242/jeb.250528 -
2025.03/27
Chlamydomonas FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins
Yamamoto R, Sahashi Y, Shimo-Kon R, Sakato-Antoku M, Suzuki M, Luo L, Tanaka H, Ishikawa T, Yagi T, King SM, Kurisu G, Kon T.
DOI: 10.1073/pnas.2423948122 -
2025.01/16
Excitable Ras dynamics-based screens reveal RasGEFX is required for macropinocytosis and random cell migration
Koji Iwamoto, Satomi Matsuoka, and Masahiro Ueda
Nature communications (2025)
DOI:https://doi.org/10.1038/s41467-024-55389-2 -
2025.01/04
Heterodimeric Ciliary Dynein f/I1 Adopts a Distinctive Structure, Providing Insight Into the Autoinhibitory Mechanism Common to the Dynein Family
Yici Lei, Akira Fukunaga, Hiroshi Imai, Ryosuke Yamamoto, Reiko Shimo-Kon, Shinji Kamimura, Kaoru Mitsuoka, Takako Kato-Minoura, Toshiki Yagi, Takahide Kon.
Cytoskeleton (2025).
DOI: https://doi.org/10.1002/cm.21987 -
2024.12/19
Chlamydomonas IC97, an intermediate chain of the flagellar dynein f/I1, is required for normal flagellar and cellular motility
Yamamoto R, Tanaka Y, Orii S, Shiba K, Inaba K, Kon T.
mSphere. 2024 Dec 19;9(12):e0055824.
doi: 10.1128/msphere.00558-24. -
2024.10/30
High-tech tracking technology streamlines drug discovery
Daisuke Watanabe, Michio Hiroshima, Masato Yasui, and Masahiro Ueda
Nature communications (2024)
DOI:https://doi.org/10.1038/s41467-024-53432-w -
2024.10/17
How studying fruit flies can help us understand congenital defects
Kevin Yuswan, Xiaofei Sun, Erina Kuranaga*, Daiki Umetsu*, *:corresponding authors,
DOI: https://doi.org/10.1371/journal.pbio.
3002823 -
2024.04/11
A non-canonical BZR/BES transcription factor regulates the development of haploid reproductive organs in Marchantia polymorpha
Tomoyuki Furuya*, Natsumi Saegusa, Shohei Yamaoka, Yuki Tomoita, Naoki Minamino, Masaki Niwa, Keisuke Inoue, Chiaki Yamamoto, Kazuki Motomura, Shunji Shimadzu, Ryuichi Nishihama, Kimitsune Ishizaki, Takashi Ueda, Hidehiro Fukaki, Takayuki Kohchi, Hiroo Fukuda, Masahiro Kasahara, Takashi Araki, and Yuki Kondo* (*co-corresponding)
Nature Plants (2024)
DOI: https://doi.org/10.1038/s41477-024-01669-0 -
2024.03/12
Chlamydomonas dynein-preassembly-deficient mutants exhibit characteristic ciliary responses to viscous media
Yamamoto R, Kitamura Y, Kon T.
MicroPubl Biol. 2024 Mar 12;2024:10.17912/micropub.biology.001149.
doi: 10.17912/micropub.biology.001149. eCollection 2024. -
2023.11/07
Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as membraneless organelles
Hiro Takakuwa, Tomohiro Yamazaki, Sylvie Souquere, Shungo Adachi, Hyura Yoshino, Naoko Fujiwara, Tetsuya Yamamoto, Tohru Natsume, Shinichi Nakagawa, Gerard Pierron, and Tetsuro Hirose
Nature Cell Biology (2023)
https://doi.org/10.1038/s41556-023-01254-1 -
2023.07/19
Landscape of semi-extractable RNAs across five human cell lines
Chao Zeng, Takeshi Chujo, Tetsuro Hirose*, Michiaki Hamada* (*co-corresponding)
Nucleic Acids Research (2023)
https://doi.org/10.1093/nar/gkad567 -
2023.05/26
Yeast Screen Uncovers Genes Involved in Chromosomal Mutation
Piyusha Mongia, Naoko Toyofuku, Ziyi Pan, Ran Xu, Yakumo Kinoshita, Keitaro Oki, Hiroki Takahashi, Yoshitoshi Ogura, Tetsuya Hayashi and Takuro Nakagawa
Communications Biology (2023)
https://doi.org/10.1038/s42003-023-04925-9 -
2023.05/16
Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
Tatsuki Yasuda, Takaya Ishihara, Ayaka Ichimura and Naotada Ishihara
Cell Reports. 2023 Apr 24;42(5):112434.
ＤＯＩ： 10.1016/j.celrep.2023.112434 -
2023.04/28
Damage Control: Plant Cells Use Mechanical Cues to Regenerate Damaged Tissues
Hiroyuki Iida, Ari Pekka Mähönen, Gerd Jürgens and Shinobu Takada
Nature Communications (2023)
https://doi.org/10.1038/s41467-023-36731-66 -
2023.02/14
Patterned proliferation orients tissue-wide stress to control root vascular symmetry in Arabidopsis
Motohiro Fujiwara*, Miyu Imamura, Katsuyoshi Matsushita, Pawel Roszak, Takafumi Yamashino, Yoichiroh Hosokawa, Keiji Nakajima, Koichi Fujimoto, Shunsuke Miyashima*
Current Biology (2023)
doi.org/10.1016/j.cub.2023.01.036 -
2023.02/07
Neural mechanism of experience-dependent sensory gain control in C. elegans
Yosuke Ikejiri, Yuki Tanimoto, Kosuke Fujita, Fumie Hiramatsu, Shuhei J. Yamazaki, Yuto Endo, Yasushi Iwatani, Koichi Fujimoto, Koutarou D. Kimura
Neuroscience Research (2023)
doi.org/10.1016/j.neures.2023.01.006 -
2023.01/17
GRAS transcription factors regulate cell division planes in moss overriding the default rule
Masaki Ishikawa*, Ayaka Fujiwara*, Ken Kosetsu*, Yuta Horiuchi*, Naoya Kamamoto*, Naoyuki Umakawa, Yosuke Tamada, Liechi Zhang, Katsuyoshi Matsushita, Gergo Palfalvi, Tomoaki Nishiyama, Sota Kitasaki, Yuri Masuda, Yoshiki Shiroza, Munenori Kitagawa, Toru Nakamura, Hongchang Cui, Yuji Hiwatashi, Yukiko Kabeya, Shuji Shigenobu, Tsuyoshi Aoyama, Kagayaki Kato, Takashi Murata, Koichi Fujimoto, Philip N. Benfey, Mitsuyasu Hasebe, Rumiko Kofuji
PNAS (2023)
doi.org/10.1073/pnas.2210632120 -
2022.11/16
New insights into mitochondrial nucleoid dynamics
Takaya Ishihara*, Reiko Ban-Ishihara*, Azusa Ota, and Naotada Ishihara
PNAS Vol.119 No.47 (2022)
doi.org/10.1073/pnas.2210730119 -
2022.09/07
Hickory dickory dock, the bean bug brain’s biological clock
Masaharu Hasebe and Sakiko Shiga,
PLOS Biology, 20(9): e3001734.
doi: 10.1371/journal.pbio.3001734. -
2022.08/01
Two-step regulation of centromere distribution by condensin II and the nuclear envelope proteins
Takuya Sakamoto*, Yuki Sakamoto*, Stefan Grob, Daniel Slane, Tomoe Yamashita, Nanami Ito, Yuka Oko, Tomoya Sugiyama, Takumi Higaki, Seiichiro Hasezawa, Maho Tanaka, Akihiro Matsui, Motoaki Seki, Takamasa Suzuki, Ueli Grossniklaus, Sachihiro Matsunaga,
Nature Plants 8, 940-953 (2022) [*:同等貢献] -
2022.07/12
A Dof-CLE circuit controls phloem organization
Pingping Qian, Wen Song, Miki Zaizen-Iida, Sawa Kume, Guodong Wang, Ye Zhang, Kaori Kinoshita-Tsujimura, Jijie Chai, and Tatsuo Kakimoto (2022). 10.1038/s41477-022-01176-0
(Nature PlantsのNews and Viewsにも取り上げられました。
doi.org/10.1038/s41477-022-01180-4) -
2022.07/07
ROP Interactive Partners are involved in control of cell division pattern in Arabidopsis leaves
Qimuge Hasi and Tatsuo Kakimoto (2022)
doi.org/10.1093/pcp/pcac089 -
2022.04/28
Fourteen New Species of Dicyemids (Phylum: Dicyemida) from Seven Species of Decapodiformes (Mollusca: Cephalopoda) in the Kumano Sea, Japan
Hidetaka Furuya and Takeya Moritaki Fourteen New Species of Dicyemids (Phylum: Dicyemida) from Seven Species of Decapodiformes (Mollusca: Cephalopoda) in the Kumano Sea, Japan.
Species Diversity 27: 181-226 (2022).
doi.org/10.12782/specdiv.27.181 -
2022.02/10
Traveling wave of inflammatory response to regulate the expansion or shrinkage of skin erythema
Sudo M, Fujimoto K (2022)
PLOS ONE 17(2): e0263049. -
2022.01/13
Improved clearing method contributes to deep imaging of plant organs
Yuki Sakamoto, Anna Ishimoto, Yuuki Sakai, Moeko Sato, Ryuichi Nishihama, Konami Abe, Yoshitake Sano, Teiichi Furuichi, Hiroyuki Tsuji, Takayuki Kohchi, and Sachihiro Matsunaga
＜DOI＞10.1038/s42003-021-02955-9 -
2021.09/08
Polymorphism in the symmetries of gastric pouch arrangements in the sea anemone Diadumene lineata
Safiye E. Sarper, Tamami Hirai, Take Matsuyama, Shigeru Kuratani, and Koichi Fujimoto
Zoological letters
＜DOI＞10.1186/s40851-021-00180-0 -
2021.07/23
Study on chromosomal rearrangements in yeast reveals potential avenue for cancer therapy
Su J, Xu R, Mongia P, Toyofuku N, Nakagawa T.
PLoS Genet 17(7), e1009671. (2021) -
2021.07/14
The path(way) less traveled in DNA double-strand break repair
Shin-Ya Isobe, Shin-ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D Donaldson, and Chikashi Obuse
Cell Reports Vol.36, Issue 2, 109383 (2021) -
2021.06/29
m6A-modification of HSATIII lncRNAs regulates temperature-dependent splicing
Kensuke Ninomiya, Junichi Iwakiri, Mahmoud Khamis Aly, ... , Tohru Natsume, Goro Terai, Kiyoshi Asai, Tsutomu Suzuki, Tetsuro Hirose.
EMBO Journal e107976 (2021) -
2021.05/31
Photoperiodic control of electrophysiological properties of the caudo-dorsal cells in the pond snail, Lymnaea stagnalis
Yoshitaka Hamanaka, Sakiko Shiga
Journal of Comparative Neurology (2021) 529: 3360-3374 -
2021.05/19
Two types of bHLH transcription factors determine the competence of pericycle for lateral root initiation
Ye Zhang, Nobutaka Mitsuda, Takeshi Yoshizumi, Yoko Horii, Yoshimi Oshima, Masaru Ohme-Takagi, Minami Matsui, Tatsuo Kakimoto
Nature Plants 7, 633-643（2021） -
2021.04/22
Paraspeckles are constructed as block copolymer micelles
Tomohiro Yamazaki*、Tetsuya Yamamoto、Hyura Yoshino、Sylvie Souquere、Shinichi Nakagawa、Gerard Pierron 、Tetsuro Hirose* (*共責任著者)
EMBO Journal e107270 (2021) -
2021.03/02
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
Kutomi O*, Yamamoto R*, Hirose K, Mizuno K, Nakagiri Y, Imai H, Noga A, Obbineni JM, Zimmermann N, Nakajima M, ....... , Nakazawa S, Sawada H, Murata K, Mitsuoka K, Ishikawa T, WakabayashiKI, Kon T, Inaba K.
Science Advances. 7(9):eabf3621 (2021). [*: 同等貢献] -
2021.02/24
Brain seasonality: Bean bug neurons need biological clock gene for seasonal egg-laying
Masaharu Hasebe, Sakiko Shiga.
Proc Natl Acad Sci U S A. 118(9):e2018823118 (2021). -
2021.03/03
Root cause: Plant root tips are constrained to a dome shape common to arch bridges
*Motohiro Fujiwara, *Tatsuaki Goh, *Satoru Tsugawa, Keiji Nakajima, Hidehiro Fukaki, and Koichi Fujimoto,
Development 148: dev196253 (2021) [*: 同等貢献] -
2020.11/20
How genes change spatial positioning for gene expression in response to environmental changes clarified
Yuki Sakamoto, Mayuko Sato, Yoshikatsu Sato, Akihito Harada, ...... , Yasuyuki Ohkawa, Ikuko Hara-Nishimura,Shingo Takagi and Sachihiro Matsunaga,
Nature Communications. 11: 5914 (2020) -
2020.11/11
Mitochondrial fission factor plays an important role in mitochondrial antiviral signaling-mediated innate immunity
Yuki Hanada, Naotada Ishihara*(責任著者), Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, and Masatoshi Nomura,
Nature Communications. 11: 5711 (2020) -
2020.05/01
Making safe choices: It’s in our DNA
Onaka AT, Su J, Katahira, Y, Tang C, Zafar F, Aoki K, Kagawa W, Niki H, Iwasaki H, Nakagawa T.
Commun Biol (2020) 3, 202. -
2020.02/20
A tadpole with a twist: Left–right asymmetric development of Oikopleura dioica
Takeshi A. Onuma, Momoko Hayashi, Fuki Gyoja, Kanae Kishi, Kai Wang and Hiroki Nishida,
Proc. Natl. Acad. Sci. USA (2020) 117(8): 4188-4198 -
2020.02/07
A crop of bilaterally symmetric flowers from inhibitory fields
Aiko Nakagawa, Miho S. Kitazawa, Koichi Fujimoto,
Development 2020 147: dev182907
doi: 10.1242/dev.182907 -
2019.11/25
Principle of size evolution: Close relationship between sexual maturation and body size
Ken-ichi Hironaka, Koichi Fujimoto, Takashi Nishimura,
iScience (2019) 20(25): 348-358. -
2019.10/15
Mother-to-embryo vitellogenin transport in a viviparous teleost Xenotoca eiseni
Atsuo Iida, Hiroyuki N. Arai, Yumiko Someya, Mayu Inokuchi, Takeshi A. Onuma, Hayato Yokoi, Tohru Suzuki, Eiichi Hondo, and Kaori Sano,
PNAS (2019) 116 (44): 22359-22365. -
2019.07/30
The complex life of a simple parasite
Tsai-Ming Lu, Miyuki Kanda, Hidetaka Furuya, and Noriyuki Satoh,
Genome Biology and Evolution (2019) 11(8):2232-2243. -
2019.04/18
Location is everything for plant cell differentiation
Iida H, Yoshida A, Takada S.
Development 146: dev169300 (2019) -
2019.01/11
Keeping Chromosomes in Check: A New Role for Heterochromatin
Akiko K. Okita, Faria Zafar, Jie Su, Dayalini Weerasekara, Takuya Kajitani, Tatsuro S. Takahashi, Hiroshi Kimura, Yota Murakami, Hisao Masukata & Takuro Nakagawa.
Communications Biology (2019),
doi:10.1038/s42003-018-0251-z -
2019.01/07
Plant peptide helps roots to branch out in the right places
Toyokura K, Goh T, Shinohara H, Shinoda A, Kondo Y, Okamoto Y, Uehara T, Fujimoto K, Okushima Y, Ikeyama Y, Nakajima K, Mimura T, Tasaka M, Matsubayashi Y, and Fukaki H.
Developmental Cell (2019) 48(1): 64-75.e5 -
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2018.12/05
The CLE9/10 secretory peptide regulates stomatal and vascular development through distinct receptors
ian P, Song W, Yokoo T, Minobe A, Wang G, Ishida T, Sawa S, Chai J, Kakimoto T.
Nature Plants 4, pages1071-1081(2018),
doi:10.1038/s41477-018-0317-4 -
2018.11/22
Gip1 structure places G proteins in lockdown
Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., and Ueda, M. (2018).
Nature Communications 9, Article number: 4635 (2018). -
2018.10/30
Molecular Inhibition Gets Cells on the Move
Matsuoka, S., and Ueda, M. (2018). “Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells”,
Nature Communications 9, Article number: 4481 (2018). -
2018.09/26
Artificial Intelligence Aids Automatic Monitoring of Single Molecules in Cells
Yasui M., Hiroshima M., Kozuka J., Sako Y., and Ueda M. (2018). “Automated single-molecule imaging in living cells”,
Nature Communications 9, Article number: 3061 -
2018.06/21
Mechanisms of DNA mismatch repair unraveled
Riki Terui, Koji Nagao, Yoshitaka Kawasoe, Kanae Taki, Torahiko L. Higashi, Seiji Tanaka, Takuro Nakagawa, Chikashi Obuse, Hisao Masukata and Tatsuro S. Takahashi (2018)
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2018.06/12
Competition for space is controlled by apoptosis-induced change of local epithelial topology
Tsuboi A, Ohsawa S, Umetsu U, Sando Y, Kuranaga E, Igaki T, Fujimoto K.
Current Biology (2018) 28(13): 2115-2128.E5 -
2017.08/30
Mixing and matching yeast DNA
Faria Zafar, Akiko K. Okita, Atsushi T. Onaka, Jie Su, Yasuhiro Katahira, Jun-ichi Nakayama, Tatsuro S. Takahashi, Hisao Masukata and Takuro Nakagawa.
Nucleic Acids Research (2017) -
2017.07/12
The fork in the road to DNA repair
Isobe S.Y., Nagao K., Nozaki N., Kimura H., Obuse C Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.
Cell Reports 20, 297 - 307 (2017) -
2017.05/22
Calcium dynamics regulating the timing of decision-making in C. elegans
Tanimoto, Y., Yamazoe-Umemoto, A., Fujita, K., Kawazoe, Y., Miyanishi, Y., Yamazaki, S. J., et al. (2017).
eLife 6, e21629. doi:10.7554/eLife.21629. -
2016.12/22
Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation
Onaka AT, Toyofuku N, Inoue T, Okita AK, Sagawa M, Su J, Shitanda T, Matsuyama R, Zafar F, Takahashi TS, Masukata H, Nakagawa T.
Nucleic Acids Res (2016) doi:10.1093/nar/gkw874 -
2016.07/12
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading
Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS.
Elife. 2016 Jul 12;5. pii: e15155. doi: 10.7554/eLife.15155. -
2016.05/19
Activity of nerve cell in freely moving animal analyzed by new robot microscope system
Tanimoto, Y., Zheng, Y. G., FEI, X., Fujie, Y., Hashimoto, K., and Kimura, K. D. (2016).
Sci. Rep. 6, 26297. doi:10.1038/srep26297. -
2016.01/25
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing
Tashiro, T., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H., Kanoh, J.
Nature Communications (2016),
doi:10.1038/ncomms10393 -
2014.12/26
Mechanisms by which Plants Repress Growth under Osmotic Stress
Kumari A, Jewaria PK, Bergmann DC, Kakimoto T. 2014. Arabidopsis reduces growth under osmotic stress by decreasing SPEECHLESS protein.
Plant Cell Physiol. 55, 2037-46. -
2013.05/30
Cell Polarity and Patterning by PIN Trafficking through Early Endosomal Compartments in Arabidopsis thaliana
Tanaka H, Kitakura S, Rakusova H, Uemura T, Feraru MI, De Rycke R, Robert S, Kakimoto T, Friml J.
PLOS Genetics (2013) 9 (5) e1003540. -
2013.04/08
ATML1 promotes epidermal cell differentiation in Arabidopsis shoots
Takada S, Takada N, Yoshida A.
Development 140, 1919-1923 (2013)