研究業績

代表的な論文

  1. Isobe S.Y., Hiraga S.I., Nagao K., Sasanuma H., Donaldson A.D., Obuse C. (2021) Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep., 36, 109383 [論文の解説] [原著論文] [PubMed]
  2. Isobe S.Y., Nagao K., Nozaki N., Kimura H., Obuse C. (2017) Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair. Cell Rep., 20, 297-307 [論文の解説] [原著論文] [PubMed]
  3. Nozawa R.S.*, Nagao K.*, Igami K.T.*, Shibata S., Shirai N., Nozaki N., Sado T., Kimura H., Obuse C. (2013) Human inactive X chromosome is compacted through a polycomb-independent SMCHD1-HBiX1 pathway. Nature Struct. Mol. Biol., 20, 566-573. *equal contribution [論文の解説] [原著論文] [PubMed]
  4. Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C. (2010) Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nature Cell Biol., 12, 719-727. [原著論文] [PubMed]
  5. Kiyomitsu T.*, Iwasaki O.*, Obuse C., Yanagida M.(2010) Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. J. Cell. Biol., 188, 791-807. *equal contribution [原著論文] [PubMed]
  6. Obuse, C.*, Iwasaki, O.*, Kiyomitsu, T., Goshima, G., Toyoda, Y. and Yanagida, M. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nature Cell Biol., 6, 1135-1141. *equal contribution [原著論文] [PubMed]

日本語総説・書籍

  1. 野澤竜介、小布施力史 (2021) ヘテロクロマチンの形成メカニズム　相分離　-メカニズムと疾患- 実験医学, 39, 1599-1604
  2. 長尾恒治、小布施力史 (2014) 次世代シーケンサーを用いた網羅的エピジェネティクス解析： ChIP-seq法など　 エピジェネティクスの産業応用 -基礎研究から産業応用への展望- (畑田出穂、久保田健夫／編) シーエムシー出版, pp120-128
  3. 長尾恒治、野澤竜介、小布施力史 (2013) バー小体の正体 - HBiX1-SMCHD1複合体によるヒト不活性化X染色体の凝縮 実験医学, 31, 1771-1775
  4. 野澤竜介、小布施力史 (2012) ヘテロクロマチンタンパク質によるAurora B キナーゼ複合体の局在と活性化のメカニズム 生化学, 84, 129-133. [PubMed] [PDF]
  5. 野澤竜介、長尾恒治、小布施力史 (2010) ヒトHP1結合タンパク質のプロテオーム解析からみえてきたHP1の新機能 - HP1はPOGZと協調してAurora Bキナーゼの活性化に寄与する-． 実験医学, 28, 2983-2987.
  6. 野澤竜介、長尾恒治、小布施力史 (2010) ヒトHP1結合タンパク質POGZは分裂前期のAurora Bキナーゼの染色体腕部での活性化に寄与する 〈Nozawa RS, et al: Nat Cell Biol (2010) 12: 719-727 〉． 細胞工学, 29, 2-4.
  7. 小布施力史 (2009) 「プロテオミクス」「ゲノミクス」「インフォーマティクス」の項． 『分子生物学』（柳田充弘・西田栄介・野田亮編：改訂版），東京化学同人
  8. 長尾恒治、野澤竜介、小布施力史 (2009) 染色体を構築する複合体のプロテオミクス解析． 明日を拓く新次元プロテオミクス，細胞工学（別冊）, 81-90.
  9. 野澤竜介、小布施力史 (2009) ヘテロクロマチン結合因子とその機能． 細胞核 - 遺伝情報制御と疾患，実験医学（増刊） 27, 123-130.
  10. 清光智美、小布施力史、柳田充弘 (2009) ブリンキン - 紡錘体形成チェックポイントと微小管結合に必須なキネトコア蛋白質． 染色体サイクル（正井久雄・升方久夫・釣本敏樹・仁木宏典・篠原 彰　編），蛋白質・核酸・酵素（増刊）, 54, 421-426.
  11. 小布施力史 (2006) 染色体分配のための分子ネットワークのプロテオミクス解析． 細胞核の世界（米田悦啓，木村宏，五十嵐和彦，中尾光善　編），蛋白質・核酸・酵素（増刊）, 51, 2020-2023.
  12. 白髭克彦、小布施力史、吉川寛 (1998) 複製開始領域の構造と染色体構築-出芽酵母の場合． DNAの複製と修復（松影照夫，花岡文雄編），実験医学（増刊）, 16, 31-40.

研究業績 全論文

  1. Mahana Y., Ariyoshi M., Nozawa RS, Shibata S., Nagao K., Obuse C., Shirakawa M. (2023) Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46. Structure, 32, 1-12 [PubMed]
  2. Obuse C., Hirose T. (2023) Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture. Curr. Opin. Cell. Biol., 85, 102250 [PubMed]
  3. Poonperm R,. Ichihara S., Miura H., Tanigawa A., Nagao K., Obuse C., Sado T., Hiratani I. (2023) Replication dynamics identifies the folding principles of the inactive X chromosome. Nat. Struct. Mol. Biol., 30, 1224-1237 [PubMed]
  4. Kuroda Y., Iwata-Otsubo A., Dias K.R., Temple S.E.L., Nagao K., De Hayr L., Zhu Y., Isobe S.Y., Nishibuchi G., Fiordaliso S.K., Fujita Y., Rippert A.L., Baker S.W., Leung M.L., Koboldt D.C., Harman A., Keena B.A., Kazama I., Subramanian G.M., Manickam K., Schmalz B., Latsko M., Zackai E.H., Edwards M., Evans C.A., Dulik M.C., Buckley M.F., Yamashita T., O'Brien W.T., Harvey R.J., Obuse C., Roscioli T., Izumi K. (2023) Dominant-negative variants in CBX1 cause a neurodevelopmental disorder. Genet. Med., 25, 100861 [PubMed]
  5. Hirano Y., Kinugasa Y., Kubota Y., Obuse C., Haraguchi T., Hiraoka Y. (2023) Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast. J Biochem., 174, 33-46 [PubMed]
  6. Masui O,. Corbel C., Nagao K., Endo T.A., Kezuka F., Diabangouaya P., Nakayama M., Kumon M., Koseki Y., Obuse C., Koseki H., Heard E. (2023) Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages. Nat. Cell. Biol., 25, 134-144 [PubMed]
  7. Sugawara S., Okada R., Loo T.M., Tanaka H., Miyata K., Chiba M., Kawasaki H., Katoh K., Kaji S., Maezawa Y., Yokote K., Nakayama M., Oshima M., Nagao K., Obuse C., Nagayama S., Takubo K., Nakanishi A., Kanemaki M.T., Hara E., Takahashi A. (2022) RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Commun. Biol., 28, 1420 [PubMed]
  8. Ichihara S., Nagao K., Sakaguchi T., Obuse C., Sado T. (2022) SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice. Development, 149, dev200864 [PubMed]
  9. Hayashi-Takanaka Y., Hayashi Y., Hirano Y., Miyawaki-Kuwakado A., Ohkawa Y., Obuse C., Kimura H., Haraguchi T., Hiraoka Y. (2021) Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry. Nucleic Acids Res. 49, 12152-12166 [PubMed]
  10. Isobe S.Y., Hiraga S.I., Nagao K., Sasanuma H., Donaldson A.D., Obuse C. (2021) Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep., 36, 109383 [PubMed]
  11. Miura H., Takahashi S., Shibata T., Nagao K., Obuse C., Okumura K., Ogata M., Hiratani I., Takebayashi SI. (2020) Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing. Nat Protoc., 15, 4058-4100 [PubMed]
  12. Sato S., Li K., Sakurai N., Hashizume M., Baidya S., Nonaka H., Noguchi K., Ishikawa K., Obuse C., Takaoka A. (2020) Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections. Cell Immunol., 356, 104188 [PubMed]
  13. Kinjo K., Nagasaki K., Muroya K., Suzuki E., Ishiwata K., Nakabayashi K., Hattori A., Nagao K., Nozawa RS., Obuse C., Miyado K., Ogata T., Fukami M., Miyado M. (2020) Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency. Sci Rep., 10, 10985 [PubMed]
  14. Hamanaka K., ŠikrovÁ D., Mitsuhashi S., Masuda H., Sekiguchi Y., Sugiyama A., Shibuya K., Lemmers RJLF., Goossens R., Ogawa M., Nagao K., Obuse C., Noguchi S., Hayashi YK., Kuwabara S., Balog J., Nishino I., van der Maarel SM. (2020) Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy. Neurology, 94, e2441-e2447 [PubMed]
  15. Ogawa-Momohara M., Muro Y., Goto K., Obuse C., Satoh M., Kono M., Akiyama M. (2020) Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. J Dermatol., 47, e217-e219 [PubMed]
  16. Okamoto K., Tanaka Y., Ogasawara S., Obuse C., Nakayama J.I., Yano H., Tsuneoka M. (2019) KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells. Oncotarget, 10, 4743-4760 [PubMed]
  17. Asakawa H., Kojidani T., Yang H.J., Ohtsuki C., Osakada H., Matsuda A., Iwamoto M., Chikashige Y., Nagao K., Obuse C., Hiraoka Y., Haraguchi T. (2019) Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast. PLoS Genet., 15, e1008061 [PubMed]
  18. Takahashi S., Miura H., Shibata T., Nagao K., Okumura K., Ogata M., Obuse C., Takebayashi S.I., Hiratani I. (2019) Genome-wide stability of the DNA replication program in single mammalian cells. Nat. Genet., 51, 529-540 [PubMed]
  19. Sakakibara Y., Nagao K., Blewitt M., Sasaki H., Obuse C., Sado T. (2018) Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice. Development, 145, dev166462 [PubMed]
  20. Terui R., Nagao K., Kawasoe Y., Taki K., Higashi T.L., Tanaka S., Nakagawa T., Obuse C., Masukata H., Takahashi T.S. (2018) Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1. Genes Dev., 32, 806-821 [PubMed]
  21. Hirata N., Suizu F., Matsuda-Lennikov M., Tanaka T., Edamura T., Ishigaki S., Donia T., Lithanatudom P., Obuse C., Iwanaga T., Noguchi M. (2018) Functional characterization of lysosomal interaction of Akt with VRK2. Oncogene, 37, 5367-5386 [PubMed]
  22. Hirano Y., Kinugasa Y., Asakawa H., Chikashige Y., Obuse C., Haraguchi T., Hiraoka Y. (2018) Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast. Genes Cells, 23, 122-135 [PubMed]
  23. Kajitani T., Kato H., Chikashige Y., Tsutsumi C., Hiraoka Y., Kimura H., Ohkawa Y., Obuse C., Hermand D., Murakami Y. (2017) Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi. Proc Natl Acad Sci U S A., 114, E11208-E11217 [PubMed]
  24. Sakata Y.*, Nagao K.*, Hoki Y., Sasaki H., Obuse C., Sado T. (2017) Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development, 144, 2784-2797. *equal contribution [PubMed]
  25. Ogushi S., Yamagata K., Obuse C., Furuta K., Wakayama T., Matzuk M.M., Saitou M. (2017) Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2. J Cell Sci., 130, 2416-2429 [PubMed]
  26. Isobe S.Y., Nagao K., Nozaki N., Kimura H., Obuse C. (2017) Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair. Cell Rep., 20, 297-307 [PubMed]
  27. Takahashi A., Okada R., Nagao K., Kawamata Y., Hanyu A., Yoshimoto S., Takasugi M., Watanabe S., Kanemaki M.T., Obuse C., Hara E. (2017) Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat Commun., 8, 15287 [PubMed]
  28. Iwamoto M., Osakada H., Mori C., Fukuda Y., Nagao K., Obuse C., Hiraoka Y., Haraguchi T. (2017) Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena. J Cell Sci., 130, 1822-1834 [PubMed]
  29. Yamaguchi L., Nishiyama A., Misaki T., Johmura Y., Ueda J., Arita K., Nagao K., Obuse C., Nakanishi M. (2017) Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation. Sci Rep., 7, 55. [PubMed]
  30. Hiraga S.I., Ly T., Garzón J., Hořejší Z., Ohkubo Y.N., Endo A., Obuse C., Boulton S.J., Lamond A.I., Donaldson A.D. (2017) Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep., 18, 403-419 [PubMed]
  31. Isono M., Niimi A., Oike T., Hagiwara Y., Sato H., Sekine R., Yoshida Y., Isobe S.Y., Obuse C., Nishi R., Petricci E., Nakada S., Nakano T., Shibata A. (2017) BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation. Cell Rep., 18, 520-532. [PubMed]
  32. Funami K., Matsumoto M., Oshiumi H., Obuse C., Seya T. (2016) The dataset of proteins specifically interacted with activated TICAM-1. Data Brief., 8, 697-699. [PubMed]
  33. Suzuki S., Kato H., Suzuki Y., Chikashige Y., Hiraoka Y., Kimura H., Nagao K., Obuse C., Takahata S., Murakami Y. (2016) Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast. Nucleic Acids Res., 44, 4147-4162. [PubMed]
  34. Funami K., Matsumoto M., Obuse C., Seya T. (2016) 14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation. Mol Immunol., 73, 60-68. [PubMed]
  35. Kaimori J.Y., Maehara K., Hayashi-Takanaka Y., Harada A., Fukuda M., Yamamoto S., Ichimaru N., Umehara T., Yokoyama S., Matsuda R., Ikura T., Nagao K., Obuse C., Nozaki N., Takahara S., Takao T., Ohkawa Y., Kimura H., Isaka Y. (2016) Histone H4 lysine 20 acetylation is associated with gene repression in human cells. Sci Rep., 6,24318. [PubMed]
  36. Hamanaka K., Goto K., Arai M., Nagao K., Obuse C., Noguchi S., Hayashi Y.K., Mitsuhashi S., Nishino I. (2016) Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations. Neuromuscul Disord., 26, 300-308. [PubMed]
  37. Tsujii A., Miyamoto Y., Moriyama T., Tsuchiya Y., Obuse C., Mizuguchi K., Oka M., Yoneda Y. (2015) Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence. J Biol Chem., 290, 29375-29388. [PubMed]
  38. Hayashi-Takanaka Y., Maehara K., Harada A., Umehara T., Yokoyama S., Obuse C., Ohkawa Y., Nozaki N., Kimura H. (2015) Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies. Chromosome Res., 23, 753-766. [PubMed]
  39. Tatematsu M., Funami K., Ishii N., Seya T., Obuse C., Matsumoto M. (2015) LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1. (2015) J Immunol., 195, 4933-4942. [PubMed]
  40. Kimoto C., Moriyama T., Tsujii A., Igarashi Y., Obuse C., Miyamoto Y., Oka M., Yoneda Y. (2015) Functional characterization of importin α8 as a classical nuclear localization signal receptor Biochim Biophys Acta., 1853, 2676-2683. [PubMed]
  41. Perpelescu M., Hori T., Toyoda A., Misu S., Monma N., Ikeo K., Obuse C., Fujiyama A., Fukagawa T. (2015) HJURP is involved in the expansion of centromeric chromatin. Mol. Biol. Cell, 26, 2742-2754. [PubMed]
  42. Moriyama T., Sangel P., Yamaguchi H., Obuse C., Miyamoto Y., Oka M., Yoneda Y. (2015) Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box. Biochem Biophys Res. Commun., 462, 201-207. [PubMed]
  43. Saito N., Qiao H., Yanagi T., Shinkuma S., Nishimura K., Suto A., Fujita Y., Suzuki S., Nomura T., Nakamura H., Nagao K., Obuse C., Shimizu H., Abe R. (2014) An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions. Sci. Transl. Med., 6, 245ra95. [PubMed]
  44. Suzuki S., Nagao K., Obuse C., Murakami Y., Takahata S. (2014) A novel method for purification of the endogenously expressed fission yeast Set2 complex. Protein Expr. Purif., 97, 44-49. [PubMed]
  45. Tanaka Y., Umata T., Okamoto K., Obuse C., Tsuneoka M. (2014) CxxC-ZF domain is needed for KDM2A to demethylate histone in rDNA promoter in response to starvation. Cell Struct. Funct., 39, 79-92. [PubMed]
  46. Hoshina S., Yura K., Teranishi H., Kiyasu N., Tominaga A., Kadoma H., Nakatsuka A., Kunichika T., Obuse C., Waga S. (2013) Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. J. Biol. Chem., 288, 30161-30171 [PubMed]
  47. Sato Y., Mukai M., Ueda J., Muraki M., Stasevich T.J., Horikoshi N., Kujirai T., Kita H., Kimura T., Hira S., Okada Y., Hayashi-Takanaka Y., Obuse C., Kurumizaka H., Kawahara A., Yamagata K., Nozaki N., Kimura H. (2013) Genetically encoded system to track histone modification in vivo. Sci. Rep., 3, 2436 [PubMed]
  48. Nozawa R.S.*, Nagao K.*, Igami K.T.*, Shibata S., Shirai N., Nozaki N., Sado T., Kimura H., Obuse C. (2013) Human inactive X chromosome is compacted through a polycomb-independent SMCHD1-HBiX1 pathway. Nature Struct. Mol. Biol., 20, 566-573. *equal contribution [論文の解説] [原著論文] [PubMed]
  49. Osakabe A., Tachiwana H., Takaku M., Hori T., Obuse C., Kimura H., Fukagawa T., Kurumizaka H. (2013) Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription. J. Cell Sci., 126, 1323-1332. [PubMed]
  50. Maehara K., Odawara J., Harada A., Yoshimi T., Nagao K., Obuse C., Akashi K., Tachibana T., Sakata T., Ohkawa Y. (2013) A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples. Nucleic Acids Res., 41, 54-62. [PubMed]
  51. Sato K., Ishiai M., Toda K., Furukoshi S., Osakabe A., Tachiwana H., Takizawa Y., Kagawa W., Kitao H., Dohmae N., Obuse C., Kimura H., Takata M., Kurumizaka H. (2012) Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J., 31, 3524-3536. [PubMed]
  52. Moriyama K., Yoshizawa-Sugata N., Obuse C., Tsurimoto T., Masai H. (2012) Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1. J. Biol. Chem., 287, 23977-23994. [PubMed]
  53. Nakaoka Y., Miki T., Fujioka R., Uehara R., Tomioka A., Obuse C., Kubo M., Hiwatashi Y., Goshima G. (2012) An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation. Plant Cell, 24, 1478-1493. [PubMed]
  54. Arai R., Tsuda M., Watanabe T., Ose T., Obuse C., Maenaka K., Minami A., Ohba Y. (2012) Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. Eur. J. Cancer, 48, 2417-2430. [PubMed]
  55. Iimori M., Ozaki K., Chikashige Y., Habu T., Hiraoka Y., Maki T., Hayashi I., Obuse C., Matsumoto T. (2012) A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules. Exp Cell Res, 318, 262-275. [PubMed]
  56. Takahashi A., Tsutsumi R., Kikuchi I., Obuse C., Saito Y., Seidi A., Karisch R., Fernandez M., Cho T., Ohnishi N., Rozenblatt-Rosen O., Meyerson M., Neel BG., Hatakeyama M. (2011) SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol. Cell, 43, 45-56. [PubMed]
  57. Fukuura M., Nagao K., Obuse C., Takahashi TS., Nakagawa T., Masukata H. (2011) CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol. Biol. Cell, 22, 2620-2633. [PubMed]
  58. Abe S., Nagasaka K., Hirayama Y., Kozuka-Hata H., Oyama M., Aoyagi Y., Obuse C, Hirota T. (2011) The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. Genes Dev. 25, 863-874. [PubMed]
  59. Tanaka T., Umemori T., Endo S., Muramatsu S., Kanemaki M., Kamimura Y., Obuse C., Araki H. (2011) Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J., 30, 2019-2030. [PubMed]
  60. Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C. (2010) Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nature Cell Biol., 12, 719-727. [原著論文] [PubMed]
  61. Watanabe A., Tatematsu M., Saeki S., Shibata S., Shime H., Yoshimura A., Obuse C., Seya T., Matsumoto M. (2011) Raftlin is involved in the nucleocapture complex to induce poly (I:C)-mediated TLR3 activation. J. Biol. Chem., 286, 10702-10711. [PubMed]
  62. Takeishi Y., Ohashi E., Ogawa K., Masai H., Obuse C., Tsurimoto T. (2010) Casein Kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1. Genes Cells, 15, 761-771. [PubMed]
  63. Matsuda M., Suizu F., Hirata N., Miyazaki T., Obuse C., Noguchi M. (2010) Characterization of the interaction of influenza virus NS1 with Akt. Biochem. Biophys. Res. Commun. , 395, 312-317. [PubMed]
  64. Osakabe A., Tachiwana H., Matsunaga T., Shiga T., Nozawa RS., Obuse C., Kurumizaka H. (2010) Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP). J. Biol. Chem., 285, 11913-11921. [PubMed]
  65. Mimura S., Yamaguchi T., Ishii S., Noro E., Katsura T., Obuse C., Kamura T. (2010) Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J. Biol. Chem. , 285, 9858-9867. [PubMed]
  66. Kiyomitsu T.*, Iwasaki O.*, Obuse C., Yanagida M.(2010) Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. J. Cell. Biol., 188, 791-807. *equal contribution [原著論文] [PubMed]
  67. Suizu F., Hiramuki Y., Okumura F., Matsuda M., Okumura AJ., Hirata N., Narita M., Kohno T., Yokota J., Bohgaki M., Obuse C., Hatakeyama S., Obata T., Noguchi M. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell, 17, 800-810. [PubMed]
  68. Perpelescu M., Nozaki N., Obuse C., Yang, H., Yoda, Y. (2009) Active establishment of centromeric CENP-A chromatin by RSF complex. J. Cell Biol., 185, 397-407. [PubMed]
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  71. Tatsumi Y., Ezura K., Yoshida K., Yugawa T., Narisawa-Saito M., Kiyono T., Ohta S., Obuse C., Fujita M.（2008） Involvement of Human ORC and TRF2 in Pre-Replication Complex Assembly at Telomeres. Gene Cells, 13, 1045-1059. [PubMed]
  72. Kimata Y, Matsuyama A, Nagao K, Furuya K., Obuse C., Yoshida M, Yanagida M.(2008) Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. J. Cell Sci., 7, 1107-1118. [PubMed]
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  74. Imura A., Tsuji Y., Murata M., Maeda R., Kubota K., Iwano A., Obuse C., Togashi K., Tominaga M., Kita N., Tomiyama K., Iijima J., Nabeshima Y., Fujioka M., Asato R., Tanaka S., Kojima K., Ito J., Nozaki K., Hashimoto N., Ito T., Nishio T., Uchiyama T., Fujimori T., Nabeshima Y. (2007) alpha-Klotho as a regulator of calcium homeostasis. Science, 15, 1615-1618. [PubMed]
  75. Saadat I., Higashi H., Obuse C., Umeda M., Murata-Kamiya N., Saito Y., Lu H., Ohnishi N., Azuma T., Suzuki A., Ohno S., Hatakeyama M. (2007) Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature, 17, 330-333. [PubMed]
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  77. Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K. (2006) Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Genes Cells, 11, 673-684. [PubMed]
  78. Nishitani H., Sugimoto N., Roukos V., Nakanishi Y., Saijo M., Obuse C., Tsurimoto T., Nakayama KI., Nakayama K., Fujita M., Lygerou Z. Nishimoto T. (2006) Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J, 25, 1126-1136. [PubMed]
  79. Obuse, C.*, Iwasaki, O.*, Kiyomitsu, T., Goshima, G., Toyoda, Y. and Yanagida, M. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nature Cell Biol., 6, 1135-1141. *equal contribution [原著論文] [PubMed]
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  81. Obuse C., Yang H., Nozaki N., Goto S., Okazaki T., Yoda K. (2004) Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. Genes Cells, 9, 105-120. [PubMed]
  82. Goshima G., Iwasaki O., Obuse C., YanagidaM. (2003) The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. EMBO J, 22, 2752-2763. [PubMed]
  83. Ohta S., Tatsumi Y., Fujita M., Tsurimoto T., Obuse C. (2003) The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. J. Biol. Chem., 278, 41535-41540. [PubMed]
  84. Tatsumi Y., Ohta S., Kimura H., Tsurimoto T., Obuse C. (2003) The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. J. Biol. Chem., 278, 41528-41534. [PubMed]
  85. Iida T., Suetake I., Tajima S., Morioka H., Ohta S., Obuse C., Tsurimoto T. (2002) PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA. Genes Cells, 7, 997-1007. [PubMed]
  86. Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. (2002) A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. J. Biol. Chem., 277, 40362-40367. [PubMed]
  87. Shiomi Y., Shinozaki A., Nakada D., Sugimoto K., Usukura J., Obuse C., Tsurimoto T. (2002) Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC. Genes Cells, 7, 861-868. [PubMed]
  88. Tadokoro R., Fujita M., Miura H., Shirahige K., Yoshikawa H., Tsurimoto T., Obuse C. (2002) Scheduled conversion of replication complex architecture at replication origins of Saccharomyces cerevisiae during the cell cycle. J. Biol. Chem., 277, 15881-15889. [PubMed]
  89. Shikata K., Ohta S., Yamada K., Obuse C., Yoshikawa H., Tsurimoto T. (2001) The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta. J. Biochem (Tokyo), 129, 699-708. [PubMed]
  90. Shiomi Y., Usukura J., Masamura Y., Takeyasu K., Nakayama Y., Obuse C., Yoshikawa H., Tsurimoto T. (2000) ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C. Proc. Natl. Acad. Sci. USA, 97, 14127-14132. [PubMed]
  91. Tatsumi Y., Tsurimoto T., Shirahige K., Yoshikawa H., Obuse C. (2000) Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures. J. Biol. Chem., 275, 5904-5910. [PubMed]
  92. Fujita M., Hori Y., Shirahige K., Tsurimoto T., Yoshikawa H., Obuse C. (1998) Cell cycle dependent topological changes of chromosomal replication origins in Saccharomyces cerevisiae. Genes Cells, 3, 737-749. [PubMed]
  93. Obuse C., Okazaki T., Masukata H. (1998) Interaction of transcription factor YY1 with a replication-enhancing element, REE1, in an autonomously replicating human chromosome fragment. Nucleic Acids Res., 26, 2392-2397. [PubMed]
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  96. Hori Y., Shirahige K., Obuse C., Tsurimoto T., Yoshikawa H. (1996) Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiae. Mol. Biol. Cell, 7, 409-418. [PubMed]
  97. Obuse C., Okuno Y., Okazaki T., Masukata H. (1996) A replication-enhancing element with transcriptional silencer activity in autonomously replicating human chromosomal fragments. Mol. Biol. Cell, 7, 43-55. [PubMed]
  98. Masukata H., Satoh H., Obuse C., Okazaki T. (1993) Autonomous replication of human chromosomal DNA fragments in human cells. Mol. Biol. Cell, 4, 1121-1132. [PubMed]