Publications

Original Papers

• Mongia P, Toyofuku N, Pan Z, Xu R, Kinoshita Y, Oki K, Takahashi H, Ogura Y, Hayashi T, Nakagawa T. Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere. Commun Biol 6, 551. (2023)

• Su J, Xu R, Mongia P, Toyofuku N, Nakagawa T. Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination. PLoS Genet 17(7), e1009671. (2021)

• Onaka AT, Su J, Katahira, Y, Tang C, Zafar F, Aoki K, Kagawa W, Niki H, Iwasaki H, Nakagawa T. DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres. Commun Biol 3, 202. (2020)

• Okita AK, Zafar F, Su J, Weerasekara D, Kajitani T, Takahashi TS, Kimura H, Murakami Y, Masukata H, Nakagawa T. Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription. Commun Biol 2, 17. (2019)

• Ogawa S, Kido S, Handa T, Ogawa H, Asakawa H, Takahashi TS, Nakagawa T, Hiraoka Y, Masukata H.Shelterin promotes tethering of late replication origins to telomeres for replication-timing control. EMBO J 37(15), e98997. (2018)

• Terui F, Nagao K, Kawasoe Y, Taki K, Higashi TL, Tanaka S, Nakagawa T, Obuse C, Masukata H, Takahashi TS. Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1. Genes Dev 32(11-12), 806-821. (2018)

• Zafar F, Okita AK, Onaka AT, Su J, Katahira Y, Nakayama J, Takahashi TS, Masukata H, Nakagawa T. Regulation of mitotic recombination between DNA repeats in centromeres. Nucleic Acids Res 45(19), 11222-11235. (2017)

• Onaka AT, Toyofuku N, Inoue T, Okita AK, Sagawa M, Su J, Shitanda T, Matsuyama R, Zafar F, Takahashi TS, Masukata H, Nakagawa T. Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation. Nucleic Acids Res 44(22), 10744-10757. (2016)

• Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS. MutSα maintains the mismatch repair capability by inhibiting PCNA unloading. eLife 5. e15155. (2016)

• Blaikley EJ, Tinline-Purvis H, Kasparek TR, Marguerat S, Sarkar S, Hulme L, Hussey S, Wee BY, Deegan RS, Walker CA, Pai CC, Bähler J, Nakagawa T, Humphrey TC. The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. Nucleic Acids Res 42(9), 5644-5656. (2014)

• Tazumi A, Fukuura M, Nakato R, Kishimoto A, Takenaka T, Ogawa S, Song J-H, Takahashi TS, Nakagawa T, Shirahige K, Masukata H. Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast. Genes Dev 26(18), 2050-2062. (2012)

• Handa T, Kanke M, Takahashi TS, Nakagawa T, Masukata H. DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol Biol Cell 23(16), 3240-3253. (2012)

• Higashi TL, Ikeda M, Tanaka H, Nakagawa T, Bando M, Shirahige K, Kubota Y, Takisawa H, Masukata H, Takahashi TS. The prereplication complex recruits XEco2 to chromatin to promote cohesin acetylation in Xenopus egg extracts. Curr Biol 22(11), 977-988. (2012)

• Kanke M, Kodama Y, Takahashi TS, Nakagawa T, Masukata H. Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J 31(9), 2182-2194. (2012)

• Maki K, Inoue T, Onaka A, Hashizume H, Somete N, Kobayashi Y, Murakami S, Shigaki C, Takahashi TS, Masukata H, Nakagawa T. An abundance of pre-replicative complexes (pre-RCs) facilitates recombinational repair under replication stress in fission yeast. J Biol Chem 286(48), 41701-41710. (2011)

• Fukuura M, Nagao K, Obuse C, Takahashi TS, Nakagawa T, Masukata H. CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol Biol Cell 22(14), 2620-2633. (2011)

• Kanke M, Nishimura K, Kanemaki M, Kakimoto T, Takahashi TS, Nakagawa T, Masukata H. Auxin-inducible protein depletion system in fission yeast. BMC Cell Biol 12, 8. (2011)

• Hayashi MT, Takahashi TS, Nakagawa T, Nakayama J, Masukata H. The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus. Nat Cell Biol 11(3), 357-362. (2009)

• Nakamura K, Okamoto A, Katou Y, Yadani C, Shitanda T, Kaweeteerawat C, Takahashi TS, Itoh T, Shirahige K, Masukata H, Nakagawa T. Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. EMBO J 27(22), 3036-3046. (2008)

• Nitani N, Yadani C, Yabuuchi H, Masukata H, Nakagawa T. Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks. Proc Natl Acad Sci USA 105(35), 12973-12978. (2008)

• Hayashi M, Katou Y, Itoh T, Tazumi M, Yamada Y, Takahashi T, Nakagawa T, Shirahige K, Masukata H. Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast. EMBO J 26(5), 1327-1339. (2007)

• Nitani N, Nakamura K, Nakagawa C, Masukata H, Nakagawa T. Regulation of DNA replication machinery by Mrc1 in fission yeast. Genetics 174(1), 155-165. (2006)

• Yabuuchi H, Yamada Y, Uchida T, Sunathvanichkul T, Nakagawa T, Masukata H. Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J 25(19), 4663-4674. (2006)

• Yamada Y, Nakagawa T, Masukata H. A novel intermediate in initiation complex assembly for fission yeast DNA replication. Mol Biol Cell 15(8), 3740-3750. (2004)

• Mazina OM, Mazin AV, Nakagawa T, Kolodner RD, Kowalczykowski SC. Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination. Cell 117(1), 47-56. (2004)

• Ono Y, Tomita K, Matsuura A, Nakagawa T, Masukata H, Uritani M, Ushimaru T, Ueno M. A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Nucleic Acids Res 31(24), 7141-7149. (2003)

• Nakagawa T, Kolodner RD. Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over. Mol Cell Biol 22(10), 3281-3291. (2002)

• Nakagawa T, Kolodner RD. The MER3 DNA helicase catalyzes the unwinding of Holliday junctions. J Biol Chem 277(31), 28019-28024. (2002)

• Nakagawa T, Flores-Rozas H, Kolodner RD. The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3' to 5' direction. J Biol Chem 276(34), 31487-31493. (2001)

• Nakagawa T, Ogawa H. The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosis. EMBO J 18(20), 5714-5723. (1999)

• Nakagawa T, Ogawa H. Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing. Genes Cells 2(1), 65-79. (1997)

Review Papers

• Xu R, Pan Z, Nakagawa T. Gross chromosomal rearrangement at centromeres. Biomolecules. 14(1), 28. (2024)

• Nakagawa T. Gross chromosomal rearrangements at the centromere. Medical Science Digest. 49(9), 64-66. (2023)

• Nakagawa T, Okita AK. Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity. Curr Genet. 65(5), 1089-1098. (2019)

• Zafar F, Nakagawa T. Regulation of minichromosome maintenance (MCM) helicase in response to replication stress. in “Fundamental aspects of DNA replication”. InTech 65-86. (2011)

• Nakagawa T, Datta A, Kolodner RD. Multiple functions of MutS- and MutL-related heterocomplexes. Proc Natl Acad Sci USA 96(25), 14186-14188. (1999)

• Ogawa H, Johzuka K, Nakagawa T, Leem SH, Hagihara AH. Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Adv Biophys 31, 67-76. (1995)