Laboratory for Advanced Brain Functions


Takatoshi HIKIDA

Neuro Biology


Institute for Protein Research



Research Theme

Our laboratory studies neural circuit mechanisms underlying various advanced brain functions such as cognitive learning and decision making behaviors using molecular techniques for neural circuit specific manipulation. We use several mouse models to reveal molecular pathologies of neuropsychiatric diseases. Especially, we focus on molecular mechanisms of gene-environment interaction in the pathogenesis of mental disorders. We also promote translational research for targeting mental disorders in collaboration with clinical departments and pharmaceutical companies.

Analysis of neural circuit mechanisms in advanced brain functions


Molecular analysis of neuropsychiatric pathologies


Translational research of mental disorders


0Cognitive learning tasks for mice


Morita et al. Dopamine D2L receptor is required for visual discrimination and reversal learning. Mol. Neuropsychiatry 2 , 124 - 132 (2016)

Macpherson et al. Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learn. Mem. 23 , 359 - 364 (2016)

Yamaguchi et al. Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron 78 , 537 - 544 (2013)

Hikida et al. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proc. Natl. Acad. Sci. U.S.A. 110 , 342 - 347 (2013)

Hikida et al. Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior. Neuron 66 , 896 - 907 (2010)

Hikida et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc. Natl. Acad. Sci. U.S.A. 104 , 14501 - 14506 (2007)


Institute for Protein Research, Osaka University
3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
tel: +81-6-6879-8623