Laboratory of Biomolecular Science and Reaction

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Professor
Shun'ichi KURODA
mail skuroda@sanken.osaka-u.ac.jp
Associate Professor
Toshihide OKAJIMA
mail tokajima@sanken.osaka-u.ac.jp
Assistant Professor
Kenji TATEMATSU
mail kenji44@sanken.osaka-u.ac.jp
Assistant Professor
Tadashi NAKAI
mail nakaix@sanken.osaka-u.ac.jp
Fields

Functional Biomolecular Biology

Belong

Institute of Scientific and Industrial Research

Location

Suita

Research Theme

The aims of this laboratory are the analysis of intermolecular reactions found in various biological phenomena, and the development of bio-industrially useful technologies by utilizing these reactions. In particular, we develop an in vivo pinpoint DDS (drug delivery system) nanocarrier (bio-nanocapsule) by mimicking the function of viruses, single cell-related technologies by utilizing an automated single cell analysis and picking up machine, an oriented immobilization technology for various biomolecules, and a bio-missile for selective degradation of pathogenic proteins in vivo. And, the active-site structures and catalytic mechanisms of various enzymes are being investigated by site-directed mutagenesis, various spectroscopies, and X-ray crystallography. Furthermore, we are conducting structural and functional analysis of bacterial two-component systems, which are involved in biofilm formation, pathogenicity, and drug resistance, to develop novel antibiotics against bacterial signal transduction.

In vivo pinpoint DDS nanocarriers (Bio-nanocapsule)

In vivo pinpoint DDS nanocarriers (Bio-nanocapsule)

Single cell-related technologies by utilizing an automated single cell analysis and picking up machine

Single cell-related technologies by utilizing an automated single cell analysis and picking up machine

Oriented immobilization technology for various biomolecules

Oriented immobilization technology for various biomolecules

Bio-missile for in vivo selective degradation of pathogenic proteins

Bio-missile for in vivo selective degradation of pathogenic proteins

Mechanisms of biogenesis of novel built-in type cofactors

Mechanisms of biogenesis of novel built-in type cofactors

Structural and functional analysis of bacterial two-component system aiming at novel drug development

Structural and functional analysis of bacterial two-component system aiming at novel drug development

Bibliography

Please visit our lab HP.

Contact

Shun'ichi KURODA Ph.D. Prof.
Department of Biomolecular Science and Reaction
The Institute of Scientific and Industrial Research (ISIR-Sanken)
Osaka University
8-1 Mihogaoka, Ibaraki, Osaka 567-0046, Japan
skuroda@sanken.osaka-u.ac.jp
Tel. +81-6-6879-8460 Fax +81-6-6879-8464

http://www.sanken.osaka-u.ac.jp/labs/smb/

http://www.sanken.osaka-u.ac.jp/en/organization/thi/thi_05/

http://www.sanken.osaka-u.ac.jp/en/organization/thi/thi_05/