Laboratory of Functional Polymer Chemistry

photo

Professor
Hiroyasu YAMAGUCHI
mail hiroyasu@chem.sci.osaka-u.ac.jp
Fields

Life Science

Belong

Graduate School of Science

Location

Toyonaka

Research Theme

In biological systems, life processes are led by the unique behavior of macromolecules such as proteins and DNA. Molecular recognition by macromolecules plays an important role, for example, in substrate specificity of enzymes and antigen-antibody reactions in human life. Selective molecular recognition among macromolecules is achieved through a large number of weak interactions. We have focused our attention on the special behavior of antibodies, especially monoclonal antibodies, because they can recognize a complex compound with high specificity. We develop novel materials through hybridization of bio-related macromolecules such as monoclonal antibodies with synthetic small molecules. We construct functionalized catalytic and energy conversion systems based on specific molecular recognition of bio-related polymers and selective assembly of bio/synthetic molecules.

Preparation of Functionalized Antibodies

We develop functionalized materials by utilizing monoclonal antibodies with various kinds of synthetic compounds.

Creation of Functionalized Materials Based on Self-Assembly of Biomolecules and / or Synthetic Polymers

Novel functional supramolecular complexes are synthesized by hybridization of biomolecules with artificial molecules.

Construction of Energy Conversion and Catalytic Systems

We construct a new type of energy-conversion system and a functionalized catalytic system.

Bibliography

Matsumoto, T.; Yamaguchi, H.; Kamijo, K.; Akiyoshi, M.; Matsunaga, T.; Harada, A. Development and Characterization of a Monoclonal Antibody against Triacetone Triperoxide Bull. Chem. Soc. Jpn 86 , 198 - 202 (2013)

Kobayashi, Y,: Takashima, Y.; Hashidzume, A.; Yamaguchi, H.; Harada, A. Reversible self-assembly of gels through metal-ligand interactions Scientific Reports 3 , 1243(1) - 1243(4) (2013)

Contact

Department of Macromolecular Science
Graduate School of Science
Osaka University
Toyonaka, Osaka 560-0043, JAPAN
Tel: +81-6-6850-5460
Fax: +81-6-6850-5457

http://www.chem.sci.osaka-u.ac.jp/lab/yamaguchi/english/index.html

http://www.chem.sci.osaka-u.ac.jp/lab/yamaguchi/english/index.html